COIOS
Behavioural science Item confirms peer-reviewed

Most US patients starting fostemsavir remained on it at 12 months in a 77-person cohort

A retrospective US cohort of 77 heavily treatment-experienced people with HIV initiating fostemsavir between 2020 and 2023 found most still on the drug at 12 months, with high adherence in the subset for whom dispensing data allowed proportion of days covered to be calculated.

Trio Health HIV Research Network data covering 77 adults prescribed fostemsavir in routine US practice between July 2020 and August 2023 were followed for 12 months, stratified by baseline viral suppression. Most remained on the drug at 12 months, and adherence was high in the subset with dispensing records; among viraemic initiators a minority reached suppression, while most suppressed initiators maintained it. CD4 counts rose in both subgroups and background regimen changes were infrequent.

Why it is interesting: A real-world persistence reading for a salvage HIV agent, though the cohort is small and adherence is not given as a number.

Source
HIV Medicine, 22 September 2026
DOI
10.1111/hiv.70303
Type
Peer-reviewed article
Design
Retrospective cohort of 77 adults initiating fostemsavir in US clinical practice, July 2020–August 2023, followed 12 months
Verdict
Confirms prior evidence
Driver
Adherence and persistence