The authors derived a treatment-predictive signal in dorsolateral and dorsomedial prefrontal cortex from fMRI of people with opioid use disorder watching Trainspotting before and after eight weeks of adjunctive treatment. An independent cohort then received real peer-guided neurofeedback or yoked sham during the same film, and real feedback increased alignment with the peer-derived target, which in turn predicted reduced craving. Sample sizes and effect sizes are not given in the abstract.
Why it is interesting: An early test of peer brain-state alignment as an addiction treatment adjunct, still far from any outcome that bears on drug mortality.