A pragmatic randomised trial recruited 278 adults whose LDL-cholesterol exceeded their risk-adapted target and allocated them to usual care with or without a self-guided digital lifestyle application. At six months the adjusted between-group difference in relative LDL change was -3.9% (p = 0.029), and 41.7% of app users achieved a fall of at least 10% against 23.8% of controls. Non-HDL-cholesterol, patient activation and quality-of-life scores also differed in favour of the app, with low attrition.
Why it is interesting: It puts a number on what an unsupervised lifestyle app adds to lipid management: statistically detectable, but small beside drug effects.