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Health todayCancer new
Myelosuppression is gemcitabine's most consistent signal in FDA adverse event reports
In 18.37 million adverse event reports made to the FDA since 2014, myelosuppression was reported 3.35 to 7.74 times more often with gemcitabine regimens than with other drugs.
Preprint · not peer-reviewed -
Health todayCancer new
Blood-based multicancer screening did not reduce late-stage cancer in 142,250 adults
In the NHS-Galleri trial of 142,250 adults in England, three annual rounds of multicancer early-detection testing did not reduce stage III or IV cancer incidence (rate ratio 1.03).
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Unemployed and unmarried Danes start cardioprotective diabetes drugs less often
Among 81,361 Danes with type 2 diabetes and cardiovascular disease, unemployed men started cardioprotective glucose-lowering drugs at 0.77 times the rate of employed men, and unemployed women 0.81 times.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Photo review found compounded products in a quarter of surveyed US GLP-1 users
Blinded review of medication photographs classified 25.8% of 322 US adults on weekly semaglutide or tirzepatide as using compounded products, with self-report agreeing for 82.6%.
Peer-reviewed -
Health todayHeart and stroke refines
Door-to-balloon under 60 minutes linked to lower mortality only in higher-risk STEMI
Among 4,513 STEMI patients in China, a door-to-balloon time over 60 minutes carried 1.69x the three-year mortality in those at higher risk on admission, but no difference at lower risk.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Walking speed predicts survival at ages 90-94, but not beyond
Among 502 adults aged 90 and over, each 0.21 m/s of faster walking speed was associated with 20% lower mortality, although the association was absent beyond age 95.
Peer-reviewed -
Tomorrow's worldMedicine at a distance refines
Pacemakers after cardiac surgery carry higher later death and heart failure risk
Among 76 223 Swedish adults having cardiac surgery, the 2.8% given a pacemaker within 30 days had a higher adjusted risk of death and of heart failure admission over 6.8 years.
Peer-reviewed -
Health todayHeart and stroke refines
GLP-1 agonists show no effect on atrial fibrillation in obese HFpEF patients
In 470 matched pairs of obese, non-diabetic patients with heart failure with preserved ejection fraction, GLP-1 receptor agonist treatment was not associated with lower atrial fibrillation incidence (HR 0.86, 95% CI 0.53-1.39), while all-cause mortality was lower (HR 0.42, 95% CI 0.23-0.75).
Peer-reviewed -
Health todayMental health new
Korean adults with depression and unstable incomes have 18% higher mortality
Among 735,922 Korean adults diagnosed with depression, those with the most variable annual incomes had 18% higher mortality over a mean 10.3 years than those with the most stable.
Peer-reviewed -
Health todayMental health confirms
Depression in US asthma patients was linked to 9.9 months shorter survival
Among 4,945 US adults with asthma, those with depressive symptoms lived 9.9 months less over 15 years, with income accounting for about a quarter of the difference.
Peer-reviewed -
Data, models and systemsAI in medicine confirms
Machine learning model predicted deaths best in diabetes with hypertension
Among 2,428 US adults with type 2 diabetes and hypertension in NHANES, a random forest predicted death with an AUC of 0.873, against 0.783 for logistic regression.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Older breast cancer survivors still score lower on physical function after ten years
Among 45,530 Women's Health Initiative participants, women with regional breast cancer scored 6.8 points below matched cancer-free women on physical function at one year and 5.3 points below at ten.
Peer-reviewed
