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Health todayHeart and stroke refines
Deaths after CPR in US hospitals remained above pre-pandemic levels through 2022
Among 612,930 weighted US hospitalisations with CPR after in-hospital cardiac arrest, 67.8% of patients died, and adjusted odds of death in 2021 were 1.26x those in 2016.
Preprint · not peer-reviewed -
Health todayDementia confirms
Lithium use was associated with 37% lower dementia risk in pooled cohort studies
A meta-analysis of 23 studies pooled four cohort studies to a hazard ratio of 0.63 for dementia among lithium users, although the authors state that causality is not established.
Peer-reviewed -
Data, models and systemsAI in medicine new
Language models identified in-hospital cardiac arrests better than ICD codes
On a hand-picked set of notes, a trained language model flagged encounters for in-hospital cardiac arrest of which 88% were genuine, against 68% for an ICD-code algorithm.
Preprint · not peer-reviewed -
Health todayHeart and stroke new
Black patients were 4% of enrolment in the defining hypertrophic cardiomyopathy trials
Across 13 of the trials that define current treatment of hypertrophic cardiomyopathy, Black patients were 3.98% of Black and White participants, as compared to 16.5% of US adults.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics new
Offering HPV vaccine at 9-10 brought median series completion to 12.2 years
In a cluster-randomised trial in 31 US paediatric practices, offering HPV vaccination at ages 9-10 rather than 11-12 brought median age at series completion forward from 13.3 to 12.2 years.
Preprint · not peer-reviewed -
Health todayHeart and stroke new
Kidney disease progressed less often on a GLP-1 drug plus SGLT2 inhibitor
Among 32,448 matched adults with chronic kidney disease, those adding a GLP-1 drug to an SGLT2 inhibitor had 0.70 times the rate of kidney disease progression over a median year.
Peer-reviewed -
Health todayMental health new
One gene variant more than triples serious mental illness risk in Colombia
Exome sequencing of 21,958 cases and 19,826 controls in a Colombian founder population identified seven genes associated with serious mental illness, one variant raising risk more than threefold.
Preprint · not peer-reviewed -
Health todayObesity, diabetes and GLP-1 confirms
Swiss children with obesity from poorer areas arrive with worse cardiometabolic risk
Among 886 children treated for obesity in Bern, ten points higher on the neighbourhood socioeconomic index was associated with lower obesity severity and lower odds of insulin resistance (OR 0.80).
Preprint · not peer-reviewed -
Health todayHeart and stroke refines
New heart failure was slightly less common on tirzepatide than semaglutide
Among 424,269 matched pairs of patients with obesity in the TriNetX records, one-year new-onset heart failure was 1.0% on tirzepatide and 1.3% on semaglutide.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence refines
Seven in ten US women stay on endocrine therapy for one year
Of 401,450 US women starting adjuvant endocrine therapy after breast surgery, 69.9% had a medication possession ratio of at least 80% over the first year.
Preprint · not peer-reviewed -
Data, models and systemsForecasts and their record refines
Polygenic scores add most to prediction where clinical risk is already low
Across 150 diseases in 900,000 UK Biobank and FinnGen participants, polygenic scores added most in metabolic, cardiovascular, autoimmune and neurological disease, and added little for genitourinary and respiratory conditions.
Preprint · not peer-reviewed -
Health todayDementia new
28% of middle-aged and older Canadians know of the hearing loss-dementia link
A survey of 1,404 Canadians found that 28% were aware of the hearing loss-dementia link, and 17% of those aware were more inclined to seek hearing-loss treatment.
Preprint · not peer-reviewed
