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Data, models and systemsValue in health contradicts
Polygenic risk-guided prostate cancer screening was not cost-effective in a UK model
In a UK-calibrated microsimulation, prostate cancer screening guided by polygenic risk scores cost more and was less effective than alternatives.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Injection-schedule adherence to long-acting cabotegravir plus rilpivirine in Spain
Among 3280 virologically suppressed adults in Spain, 70.4% received every evaluable injection within ±7 days; 0.7% had suboptimal adherence.
Peer-reviewed -
Health todayDementia refines
Education and dementia: a schooling reform cut incidence and weakened genetic risk
A compulsory schooling reform showed that extra education lowered dementia incidence and weakened the link between genetic risk and dementia.
Peer-reviewed -
Health todayHeart and stroke refines
Cardiovascular disease burden in Europe is similar by sex but differs in composition
In 2023 women had 55% of cardiovascular cases and 50% of deaths, but less ischaemic heart disease.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Antibiotic use in patients hospitalised for COVID-19 across 64 countries, 2020 to 2023
Of 451,291 patients hospitalised for COVID-19 in 64 countries, 341,125 received antibiotics, mostly empirical WHO 'Watch' drugs.
Peer-reviewed -
Behavioural scienceSmoking and vaping new
Nicotine pouch use in British quit attempts rose 2021-2026, notably among 18-24s and men
Among British adults trying to stop smoking, pouch use nearly tripled to 6.7%, with an uncertain adjusted link to quitting.
Preprint · not peer-reviewed -
Behavioural scienceSmoking and vaping refines
Switching from cigarettes to e-cigarettes and human biomarkers of toxicant exposure
Complete switching from cigarettes to e-cigarettes was linked to lower levels of all ten pooled toxicant exposure biomarkers.
Peer-reviewed -
Behavioural scienceAlcohol and drug use new
Medetomidine appeared in about a quarter of Southern California fentanyl samples by 2026
Medetomidine was first detected in Southern California fentanyl in May 2025 and was present in about 25% by August 2026.
Preprint · not peer-reviewed -
Health todayHeart and stroke refines
Coronary artery calcium in adults aged 30 to 45 and mortality over a median 22.6 years
Among 12,847 adults aged 30 to 45, coronary calcium above 90% had a hazard ratio of 3.71 for coronary death.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 receptor agonists lower weight and HbA1c in adults taking antipsychotics
In eight trials of antipsychotic-treated adults, GLP-1 receptor agonists lowered weight by 6.54 kg but raised nausea, vomiting and constipation.
Peer-reviewed -
Data, models and systemsAI in medicine new
Video-and-audio AI system detected stroke deficits more sensitively than EMS raters
Against a consensus of seven neurologists, an AI system reading video and audio of 295 suspected stroke patients detected neurological deficits with 78.5% sensitivity, versus 59.4% for emergency medical services (EMS) personnel, with similar specificity.
Preprint · not peer-reviewed -
Health todayCancer confirms
Head and neck cancer in New Zealand: rising oropharyngeal rates and unequal early deaths
New Zealand oropharyngeal cancer rates rose in 2009-2020, with higher two-year deaths for Māori, Pacific Peoples and the most deprived.
Peer-reviewed
