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Health todayCancer new
Genomic testing reached 38% of Ohio Medicaid women with ER-positive early breast cancer
Among 1,988 Ohio Medicaid patients with early ER-positive breast cancer, 37.8% received Oncotype DX or MammaPrint within six months, with receipt lower for regional than localised disease (aOR 0.35).
Peer-reviewed -
Behavioural scienceAlcohol and drug use confirms
Fentanyl was present in three quarters of cocaine overdose deaths in Cuyahoga County
Of 1,150 unintentional cocaine-related overdose deaths in Cuyahoga County, Ohio, from 2014 to 2024, fentanyl was also present in 74.6%, with the two groups differing by age and race.
Peer-reviewed -
Health todayDementia new
Inherited small vessel disease carriers had higher odds of a worse dementia rating
Carriers of a NOTCH3 variant causing CADASIL, an inherited small vessel brain disease, had 2.55 to 5.08 times the odds of a more impaired dementia rating than non-carrier relatives.
Preprint · not peer-reviewed -
Health todayHeart and stroke new
GLP-1 prescribing without an approved indication rose fifteenfold in US adults
Among 92.4 million US adults with no recorded type 2 diabetes or qualifying obesity, GLP-1 prescribing rose from 0.1% in 2021 to 1.5% in 2025.
Peer-reviewed -
Data, models and systemsHealth systems and access contradicts
Despair did not explain rising midlife mortality among white US adults
Among US adults aged 45-54 between 1999 and 2015, death rates rose for white adults, but the 0.13% rise in reported despair did not track that increase.
Peer-reviewed -
Data, models and systemsAI in medicine refines
AI reading breast pathology slides identified which patients gained from chemotherapy
Applied to 6,735 TAILORx trial patients without retraining, an AI model reading pathology slides identified intermediate-risk patients who gained 5 percentage points in five-year disease-free interval from chemotherapy.
Preprint · not peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Former US service members die more often of alcohol, drugs or suicide than civilians
Among 176,719 deaths at ages 18-64 in Massachusetts and Minnesota, alcohol, drug and suicide causes accounted for 12% and 7% more of former service members' deaths than of non-military deaths.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Social media alerts driven by wastewater data did not raise seasonal vaccination
A county-randomised trial across 40 New York State counties found that an 11-week campaign of wastewater-triggered social media alerts made no difference to COVID-19 or influenza vaccination over the season.
Preprint · not peer-reviewed -
Health todayHeart and stroke confirms
Empagliflozin's lower cardiovascular risk is similar across social groups in Medicare
In US Medicare claims, empagliflozin initiators aged 65 and over had a hazard ratio of 0.77 for major cardiovascular events against DPP-4 inhibitors, with no variation by social group.
Peer-reviewed -
Data, models and systemsHealth systems and access confirms
US life expectancy ranked 38th in 2023 and the gap has widened
US life expectancy ranked 38th in 2023, with the gap against 16 high-income countries widening and rising death rates concentrated at younger and working ages.
Peer-reviewed -
Health todayDementia refines
Only the intelligence part of an education genetic score tracks Alzheimer's
Across four cohorts of 3,483 participants, the intelligence-linked part of an education genetic score was inversely associated with Alzheimer's diagnosis, while the behavioural part was not.
Peer-reviewed -
Health todayHeart and stroke confirms
SGLT2 inhibitors show no new safety signals in diabetic kidney disease
In two US claims cohorts with type 2 diabetes and stage III to IV kidney disease, SGLT2 inhibitors showed only the known genital infection signal against GLP-1 receptor agonists.
Peer-reviewed
