-
Behavioural scienceAdherence and persistence refines
Seven in ten US women stay on endocrine therapy for one year
Of 401,450 US women starting adjuvant endocrine therapy after breast surgery, 69.9% had a medication possession ratio of at least 80% over the first year.
Preprint · not peer-reviewed -
Health todayCancer new
Myelosuppression is gemcitabine's most consistent signal in FDA adverse event reports
In 18.37 million adverse event reports made to the FDA since 2014, myelosuppression was reported 3.35 to 7.74 times more often with gemcitabine regimens than with other drugs.
Preprint · not peer-reviewed -
Data, models and systemsForecasts and their record new
Modelled summer COVID-19 vaccination averts more US hospitalisations in over-65s
A US transmission model estimated 441 COVID-19 hospitalisations per 100,000 adults aged 65 and over under July vaccination, as compared to 578 with no further vaccination.
Preprint · not peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Photo review found compounded products in a quarter of surveyed US GLP-1 users
Blinded review of medication photographs classified 25.8% of 322 US adults on weekly semaglutide or tirzepatide as using compounded products, with self-report agreeing for 82.6%.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Walking speed predicts survival at ages 90-94, but not beyond
Among 502 adults aged 90 and over, each 0.21 m/s of faster walking speed was associated with 20% lower mortality, although the association was absent beyond age 95.
Peer-reviewed -
Health todayHeart and stroke refines
GLP-1 agonists show no effect on atrial fibrillation in obese HFpEF patients
In 470 matched pairs of obese, non-diabetic patients with heart failure with preserved ejection fraction, GLP-1 receptor agonist treatment was not associated with lower atrial fibrillation incidence (HR 0.86, 95% CI 0.53-1.39), while all-cause mortality was lower (HR 0.42, 95% CI 0.23-0.75).
Peer-reviewed -
Health todayMental health confirms
Depression in US asthma patients was linked to 9.9 months shorter survival
Among 4,945 US adults with asthma, those with depressive symptoms lived 9.9 months less over 15 years, with income accounting for about a quarter of the difference.
Peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Most people with HIV starting fostemsavir were still taking it a year later
A retrospective cohort of 77 adults starting fostemsavir in US clinical practice found most still taking it at 12 months, and most of those already suppressed stayed suppressed.
Peer-reviewed -
Data, models and systemsAI in medicine confirms
Machine learning model predicted deaths best in diabetes with hypertension
Among 2,428 US adults with type 2 diabetes and hypertension in NHANES, a random forest predicted death with an AUC of 0.873, against 0.783 for logistic regression.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Older breast cancer survivors still score lower on physical function after ten years
Among 45,530 Women's Health Initiative participants, women with regional breast cancer scored 6.8 points below matched cancer-free women on physical function at one year and 5.3 points below at ten.
Peer-reviewed -
Health todayCancer confirms
Kidney cancer mortality fell in Medicaid expansion states, but not for Black patients
Among 284,967 US adults aged 40 to 64 with renal cell carcinoma, overall mortality was 7.5% lower in Medicaid expansion states, with no change in five-year survival for Black patients.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Liraglutide's benefit in US veterans may be larger than the LEADER trial found
Reweighting the LEADER trial onto US veterans with diabetes gave a three-year reduction in major cardiovascular events of 4.6% against 1.6%, a difference within statistical uncertainty.
Peer-reviewed
