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Behavioural scienceAdherence and persistence new
Fewer than one in five US stroke and TIA patients filled a P2Y12 inhibitor
Among 45,763 US adults with a first ischaemic stroke or TIA, 18.9% filled a P2Y12 inhibitor within 30 days, and half of clopidogrel initiators had stopped filling by 180 days.
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
Tirzepatide initiators stayed on treatment longer than semaglutide initiators
In propensity-matched US claims data on adults with type 2 diabetes, 12-month adherence was 60% for tirzepatide initiators against 45% for semaglutide initiators among GLP-1-naive patients, with persistence of 62% against 47%.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
GLP-1 prescribing to US children aged 8-11 with obesity rose but stayed under 1%
Among 3.5 million US children aged 8 to 11 with obesity and without diabetes recorded in Epic Cosmos between 2019 and June 2026, 0.6% received a GLP-1 receptor agonist prescription, with rates highest among 11-year-olds, girls, and those with obesity-related comorbidities.
Peer-reviewed -
Data, models and systemsAI in medicine new
Language models identified overdose deaths from New York investigators' written reports
Reading the reports New York City death investigators write on each case, the better of two language models identified suspected overdose deaths with 92% sensitivity and 88% positive predictive value.
Peer-reviewed -
Behavioural scienceAlcohol and drug use new
One in nine older US cannabis users meets criteria for cannabis use disorder
In a national US survey, 8.9% of adults aged 65 and over had used cannabis in the past year, and 11.4% of those met criteria for cannabis use disorder.
Peer-reviewed -
Data, models and systemsValue in health new
Modelled hepatitis B cure is cost-effective under USD46,642 a course in the US
A Markov model estimated that a hepatitis B cure regimen working in 30% of patients would be cost-effective at a one-off price below USD46,642 in the US.
Peer-reviewed -
Behavioural scienceSocial connection refines
Loneliness predicts psychological distress better than other social measures
In a 29-country European survey of 48,377 respondents, loneliness was the strongest social predictor of psychological distress, and the other social measures together added 0.006 to the AUC.
Peer-reviewed -
Health todayDementia refines
APOE e4 dementia risk is largest in European ancestry across 367,757 US adults
A study of APOE genotype against 2,632 traits and conditions in 367,757 All of Us participants found 27 associations, with dementia risk largest in those of European ancestry.
Preprint · not peer-reviewed -
Health todayHeart and stroke refines
Deaths after CPR in US hospitals remained above pre-pandemic levels through 2022
Among 612,930 weighted US hospitalisations with CPR after in-hospital cardiac arrest, 67.8% of patients died, and adjusted odds of death in 2021 were 1.26x those in 2016.
Preprint · not peer-reviewed -
Health todayHeart and stroke new
Black patients were 4% of enrolment in the defining hypertrophic cardiomyopathy trials
Across 13 of the trials that define current treatment of hypertrophic cardiomyopathy, Black patients were 3.98% of Black and White participants, as compared to 16.5% of US adults.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics new
Offering HPV vaccine at 9-10 brought median series completion to 12.2 years
In a cluster-randomised trial in 31 US paediatric practices, offering HPV vaccination at ages 9-10 rather than 11-12 brought median age at series completion forward from 13.3 to 12.2 years.
Preprint · not peer-reviewed -
Health todayHeart and stroke refines
New heart failure was slightly less common on tirzepatide than semaglutide
Among 424,269 matched pairs of patients with obesity in the TriNetX records, one-year new-onset heart failure was 1.0% on tirzepatide and 1.3% on semaglutide.
Preprint · not peer-reviewed
