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Behavioural scienceAlcohol and drug use refines
Drug-poisoning deaths are set against the change in US life expectancy, 2019 to 2024
A cross-sectional study examines how far changes in drug-poisoning deaths account for the change in US life expectancy between 2019 and 2024.
Peer-reviewed -
Tomorrow's worldA changing climate refines
Wildfire smoke PM2.5 is associated with higher dementia incidence in older US adults
Each microgram per cubic metre of wildfire smoke PM2.5 was associated with a 2.9% increase in the incidence rate of dementia among 39.7 million US Medicare beneficiaries followed to 2019.
Preprint · not peer-reviewed -
Data, models and systemsHealth systems and access refines
US county excess deaths linked to education and insurance coverage
A screen of 2,745 county-level variables found the strongest correlates of US county excess deaths were college attainment (-0.54) and uninsurance at ages 40-64 (+0.53).
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence new
Most adults starting semaglutide or tirzepatide did not continue for a year
Among 743,153 US adults starting semaglutide or tirzepatide for obesity in 2024, 29.9% and 35.9% respectively were still being prescribed the drug at 12 months.
Preprint · not peer-reviewed -
Health todayCancer new
Menopausal hormone therapy users had higher breast cancer incidence but lower mortality
In 78,209 women in the PLCO screening trial, ever use of menopausal hormone therapy was associated with higher breast cancer incidence (aHR 1.17) and lower breast cancer mortality (0.72).
Preprint · not peer-reviewed -
Behavioural scienceSmoking and vaping new
Nicotine pouch take-up is higher among US adults using other tobacco products
In the PATH study of 24,640 US adults, those using smokeless tobacco only took up oral nicotine pouches at 42.4 times the rate of adults using no other tobacco product.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Older adults starting GLP-1 drugs were younger and heavier than other initiators
Among 58,754 adults aged 65 and over with type 2 diabetes, mean BMI at initiation was 33.8 for GLP-1 drugs as compared to 29.7 for SGLT2 inhibitors.
Preprint · not peer-reviewed -
Health todayCancer refines
Under 2 mm of Gleason pattern 4 matches favourable intermediate-risk prostate cancer
Among 2499 men with Grade Group 2-4 prostate cancer, those with under 2 mm of Gleason pattern 4 had 5-year biochemical recurrence of 20%, matching favourable intermediate-risk disease.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
An estimated 1.32% of US adults had hepatitis C in 2017-2020
An estimated 1.32% of US adults, or 3.33 million people, had hepatitis C over 2017-2020, on a model combining six surveillance, claims and Medicaid sources.
Preprint · not peer-reviewed -
Health todayHeart and stroke confirms
US deaths recording both type 2 diabetes and cardiac arrest rose faster after 2014
Deaths of US adults recording both type 2 diabetes and cardiac arrest rose by 2.72% a year to 2014, then by 9.55% a year to 2020.
Peer-reviewed -
Behavioural scienceInfection and pandemics confirms
VAERS reports after the 2024-25 COVID-19 vaccine were consistent with earlier seasons
A CDC review of 9856 US VAERS reports following the 2024-2025 JN.1-based COVID-19 vaccine found 8.9% serious, eight Guillain-Barre and six myocarditis or myopericarditis cases meeting case definitions, with reporting rates below background rates for both.
Peer-reviewed -
Data, models and systemsValue in health new
Sotagliflozin after worsening heart failure is modelled at $75,510 per QALY gained
A lifetime microsimulation of patients with type 2 diabetes after worsening heart failure put sotagliflozin at $75,510 per quality-adjusted life-year gained, at an assumed net cost of $434 a month.
Peer-reviewed
