The Da Qing cohort of 540 adults with impaired glucose tolerance was split by weight change over the six-year lifestyle intervention and followed for 34 years. Participants losing 5% or more of baseline weight had hazard ratios of 0.67 for all-cause death, 0.56 for cardiovascular death and 0.48 for heart failure hospitalisation relative to those with no weight loss, although grouping by weight change after randomisation is a post hoc comparison. Median time to cardiovascular death was 6.5 years later in the high weight loss group.
Why it is interesting: A 34-year follow-up of mortality by early weight change in people with impaired glucose tolerance.