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Behavioural scienceInfection and pandemics confirms
Infant RSV hospitalisations fell two thirds in Quebec's first nirsevimab season
In Quebec's first season of offering nirsevimab to all infants, hospitalisations with a positive RSV test in those aged 0-5 months fell by 66%, and bronchiolitis emergency visits by 35%.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
GLP-1 drugs did not reduce new sleep apnoea diagnoses in UK diabetes patients
Among UK adults with type 2 diabetes and obesity, those starting a GLP-1 drug rather than a weight-neutral DPP-4 inhibitor had no fewer new sleep apnoea diagnoses (hazard ratio 1.07).
Peer-reviewed -
Health todayCancer new
Oral KRAS G12D inhibitor GFH375 shrank tumours in a third of pancreatic cancers
In 74 heavily pretreated patients with KRAS G12D-mutant advanced solid tumours, the oral inhibitor GFH375 produced confirmed responses in 35.1% of pancreatic cancers and 35.7% of lung cancers.
Peer-reviewed -
Health todayDementia new
Most dementia trial participants had more than one brain pathology at autopsy
Among 67 autopsied participants in dementia trials at a Kentucky research centre, only 10 to 29% had solely the pathology that the trial's intervention was designed to target.
Peer-reviewed -
Health todayCancer new
Wildfire smoke is linked to shorter survival in older US lung cancer patients
A SEER-Medicare cohort of 414,016 patients aged 65 or older with lung cancer found shorter overall survival with higher long-term exposure to wildfire-related fine particles.
Peer-reviewed -
Health todayCancer new
Blood test used with the standard marker CA19-9 detected early-stage pancreatic cancer
A prospective study of 1,785 people across four countries reports that an exosome-based blood test, used with the standard marker CA19-9, detected early-stage pancreatic cancer with high sensitivity.
Peer-reviewed -
Data, models and systemsAI in medicine new
Language model identifies neurodegenerative disease from autopsy text in 75% of cases
In 5,613 Mayo Clinic autopsies, a language model scoring gross brain descriptions gave the correct diagnosis in 75% of held-out cases, but rarely identified combined Alzheimer and Lewy body disease.
Preprint · not peer-reviewed -
Data, models and systemsAI in medicine new
A locally run AI system removed 99.8% of identifiers planted in patient records
Of identifiers planted in 250 MIMIC-IV records extended with scans, handwriting and audio, 99.82% were removed, with every identifier removed for 98.80% of patients.
Preprint · not peer-reviewed -
Health todayDementia confirms
Known dementia risk factors explain only part of exceptional cognition in older age
Education, absence of high blood pressure, lower depression, diet and social contact were each only modestly associated with exceptionally high memory in 3,513 Whitehall II participants aged 65 or over.
Preprint · not peer-reviewed -
Behavioural scienceSocial connection new
Socioeconomic circumstances track the gap between loneliness and contact in older adults
In 8,164 English adults aged 60 and over followed from 2014 to 2019, personal and area circumstances both tracked how lonely people felt for the contact they had.
Peer-reviewed -
Health todayCancer confirms
Vaccinated Spanish women have less HPV 16/18 and fewer high-grade cervical lesions
Among 908 women in population-based cervical screening in Spain, HPV 16/18 was detected in 0.76% of vaccinated women as compared to 5.5% of unvaccinated women.
Preprint · not peer-reviewed -
Behavioural scienceSmoking and vaping refines
Power to Quit campaign coincided with more quit attempts but no change in success
A pre/post evaluation of England's Power to Quit mass media campaign found quit attempts rose from 48.4% to 52.3% and use of digital support from 16.0% to 18.4%, both with confidence intervals spanning no effect, and no clear change in quit success.
Preprint · not peer-reviewed
