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Item contradicts peer-reviewed
Reanalysed mammography trials are compatible with overdiagnosis below 5%
A reanalysis of randomised mammography trials, benchmarked against Denmark's Funen screening programme and adjusting for exit screening and follow-up timing, found excess-incidence patterns compatible with breast cancer overdiagnosis below 5%, against published estimates of up to 50%.
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Item new preprint
Canada's 2025/26 flu vaccine cut A(H3N2) subclade K illness by about a third
In Canada's sentinel outpatient network for 2025/26, vaccine effectiveness was 38% against A(H3N2) overall and 33% against the antigenically mismatched subclade K, 28% against A(H1N1)pdm09 and 55% against B/Victoria.
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Item refines preprint
Austrian registry data show vaccinated adults died less from causes vaccines cannot affect
In Austrian adults with no documented prior infection, vaccinated people had lower mortality from cancer and external causes, with adjusted all-cause hazard ratios of 0.24 to 0.32 in the two weeks after a dose, a measure of the healthy vaccinee effect.
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Item new preprint
Mortality from secondary lung cancer rose 17.5% above 2000 levels in the US by 2024
Secondary malignant neoplasm of the lung (C78.0) recorded on death certificates rose from 7.22 per 100,000 population in 2008 to 11.38 in 2024, 17.5% above 2000 levels, with disproportionate increases among adults aged 25–34 years (70.5%).
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Item refines peer-reviewed
Healthy working life expectancy at 50 averaged 11 years across 28 countries
In a 28-country cohort of 175,318 adults aged 50 and over, healthy working life expectancy at 50 was 10.98 years, 9.82 for women and 12.36 for men, with stroke associated with a 5.49-year reduction and higher health spending, governance quality and flexible work arrangements with longer spans.
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Item new preprint
Long-run mortality from tropical cyclones concentrates in socially vulnerable counties
Among high-vulnerability counties in Texas, tropical cyclone exposure was associated with elevated all-cause mortality persisting long after landfall, whereas the effect in lower-vulnerability counties was not statistically significant.
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Item confirms peer-reviewed
Social role participation shows dose-response association with lower systemic inflammation
Greater social role participation was associated with lower systemic inflammation, with a graded pattern showing progressively stronger benefits across increasing levels of social integration compared to isolation.
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Item refines preprint
Chronic loneliness associates with worse health and functioning in older age
Chronic loneliness was longitudinally associated with worse general health, functional capacity and mental wellbeing in 4,090 older English adults, with isolation patterns showing reversible effects on cognition and mental health.
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Item confirms peer-reviewed
Home-based care use varies across Japan's municipalities despite universal insurance
Home-based long-term care services in Japan show significant geographic clustering and variation despite universal insurance coverage, associated with municipal characteristics including financial strength and care provider availability.
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Item refines peer-reviewed
Polygenic score for osteoporosis shows modest discrimination gain in Japanese adults
A Japanese-ancestry polygenic score for ultrasound-defined osteoporosis added little to discrimination beyond age and sex, but quintile stratification gave incidence rate ratios of 1.42 in the lowest and 0.70 in the highest quintile over a mean 3.5 years of follow-up.
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Item refines peer-reviewed
Weight loss drives bone loss through endocrine, nutritional and mechanical mechanisms
Weight loss raises bone turnover and lowers bone mineral density via endocrine, nutritional, mechanical and microbiota-mediated pathways, with greater loss in older and lean adults and after severe caloric restriction such as with GLP-1 drugs or bariatric surgery.
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Item refines peer-reviewed
Viral coinfections were not linked to severe COVID-19 in systematically tested children
Among 938 Canadian children hospitalised with COVID-19 at centres testing all acute respiratory admissions, the 18.6% with at least one other respiratory virus had no higher odds of severe disease (aOR 0.94, 95% CI 0.76–1.15).
