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Behavioural scienceInfection and pandemics refines
Scotland's strep A surge brought no new variant of the dominant strain
Scottish national surveillance of 3,408 invasive strep A infections found the late-2022 surge coincided with influenza and RSV, with isolates of the dominant strain type unchanged from before the pandemic.
Peer-reviewed -
Health todayHeart and stroke new
Norwegian stroke rates fell over 20 years, except strokes linked to atrial fibrillation
Across 227,575 strokes in Norway from 2001 to 2021, ischaemic stroke fell from 204.4 to 130.8 per 100,000 person-years in people without atrial fibrillation, but not in those with it.
Peer-reviewed -
Health todayHeart and stroke new
Atrial fibrillation recurrence after ablation was similar on GLP-1, SGLT2 or both
Among adults having catheter ablation for atrial fibrillation, recurrence was similar on a GLP-1 drug, an SGLT2 inhibitor or both, while all-cause mortality was lower on the combination.
Peer-reviewed -
Health todayHeart and stroke refines
Heart-type fatty acid-binding protein detects coronary disease poorly but tracks deaths
Heart-type fatty acid-binding protein detected coronary disease poorly in 2,690 patients, but eight-year mortality rose from 7.7% in the lowest quartile of the marker to 44% in the highest.
Peer-reviewed -
Behavioural scienceDiet, exercise and sleep refines
Adolescent movement behaviours explained 2.0 points of a 6.9-point CVD risk gap
In 6,608 US adolescents followed for over two decades, the 6.9 percentage-point gap in predicted 30-year cardiovascular risk by parental education fell to 4.9 points in a scenario removing all unhealthy physical activity, screen time and sleep, and the relative gap was unchanged.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 confirms
GLP-1/GIP agonist BGM0504 reduced weight by up to 18% at 24 weeks
In 120 Chinese adults with overweight or obesity and no diabetes, weekly BGM0504 reduced weight by 10.7% to 18.3% at 24 weeks, as compared to no change on placebo.
Peer-reviewed -
Health todayCancer refines
Familial adenomatous polyposis found by screening matches general population mortality
Relatives found by family screening to have familial adenomatous polyposis had mortality comparable to the general population (median SMR 0.66), against 11.09 for patients presenting with symptoms.
Peer-reviewed -
Health todayDementia refines
Blood p-tau217 tracked Alzheimer's-type brain shrinkage but not ordinary ageing
Among 818 adults with no cognitive symptoms in the Baltimore Longitudinal Study of Aging, p-tau217 was the only blood marker associated with later shrinkage of the medial temporal lobe.
Preprint · not peer-reviewed -
Behavioural scienceSocial connection new
Enriched Head Start preschool improved 7 of 11 well-being measures by age 21
Adding intensive social-emotional and language support to Head Start classrooms improved 7 of 11 well-being measures at ages 21 to 22, in a randomised trial of 356 children.
Peer-reviewed -
Health todayCancer new
A model puts daraxonrasib at $500,637 per quality-adjusted life year in pancreatic cancer
A cost-effectiveness model built from the RASolute 302 trial put daraxonrasib at $500,637 per quality-adjusted life year gained over chemotherapy, at a US price of $39,800 per 30 days.
Preprint · not peer-reviewed -
Health todayCancer refines
Cancer polygenic scores were weaker in African-ancestry than European-ancestry veterans
Across 560,287 US veterans, all 13 cancer polygenic scores were associated with their own cancer in European-ancestry participants, but only five of 13 were in African-ancestry participants.
Peer-reviewed -
Health todayHeart and stroke new
Women and deprived patients had higher one-year mortality in English aortic disease
Among 33,793 new thoracic aortic disease diagnoses in England between 2013 and 2018, one-year mortality was higher among women, older patients and those from deprived areas, and patients from deprived areas were less likely to receive early intervention or genetic referral.
Peer-reviewed
