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Behavioural scienceDiet, exercise and sleep refines
Adolescent movement behaviours explained 2.0 points of a 6.9-point CVD risk gap
In 6,608 US adolescents followed for over two decades, the 6.9 percentage-point gap in predicted 30-year cardiovascular risk by parental education fell to 4.9 points in a scenario removing all unhealthy physical activity, screen time and sleep, and the relative gap was unchanged.
Peer-reviewed -
Health todayDementia refines
Blood p-tau217 tracked Alzheimer's-type brain shrinkage but not ordinary ageing
Among 818 adults with no cognitive symptoms in the Baltimore Longitudinal Study of Aging, p-tau217 was the only blood marker associated with later shrinkage of the medial temporal lobe.
Preprint · not peer-reviewed -
Behavioural scienceSocial connection new
Enriched Head Start preschool improved 7 of 11 well-being measures by age 21
Adding intensive social-emotional and language support to Head Start classrooms improved 7 of 11 well-being measures at ages 21 to 22, in a randomised trial of 356 children.
Peer-reviewed -
Health todayCancer new
A model puts daraxonrasib at $500,637 per quality-adjusted life year in pancreatic cancer
A cost-effectiveness model built from the RASolute 302 trial put daraxonrasib at $500,637 per quality-adjusted life year gained over chemotherapy, at a US price of $39,800 per 30 days.
Preprint · not peer-reviewed -
Health todayCancer refines
Cancer polygenic scores were weaker in African-ancestry than European-ancestry veterans
Across 560,287 US veterans, all 13 cancer polygenic scores were associated with their own cancer in European-ancestry participants, but only five of 13 were in African-ancestry participants.
Peer-reviewed -
Health todayMental health new
One in five Black US students left the suicide attempt question blank
Across 163,489 US high school students surveyed from 2001 to 2021, the suicide attempt question was left blank by 21.6% of Black adolescents and 7.1% of white adolescents.
Peer-reviewed -
Health todayDementia confirms
AT2-stimulating antihypertensives were linked to less dementia in two US cohorts
In 1.6 million Medicare beneficiaries and 80,267 Vanderbilt patients aged 65 and over with hypertension, incident Alzheimer's disease and related dementias were less common among users of angiotensin II receptor-stimulating than receptor-inhibiting antihypertensives (6.7% against 8.2% in Medicare).
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Most US adults starting a GLP-1 obesity drug stop within the year
Among 201,229 insured US adults with obesity and no diabetes starting a GLP-1 drug, 30.7% stayed on it for most of the following year, as did 20.3% of paediatric patients.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Diabetes was more common in older US influenza deaths than in COVID-19 deaths
Among US inpatients aged over 65 who died, 46.6% of those dying of COVID-19 had diabetes, as compared to 63.1% of those dying of influenza.
Peer-reviewed -
Health todayCancer refines
Pancreatic cancer risk on GLP-1 drugs depends on the diabetes drug compared
Pancreatic cancer was less common in GLP-1 starters than in starters of four other diabetes classes, while against insulin the paper reports a lower hazard but a higher absolute risk.
Peer-reviewed -
Health todayHeart and stroke confirms
Cardiogenic shock deaths fall as hospital cardiac capability rises in US admissions
Across an estimated 1.18 million US admissions for cardiogenic shock, crude in-hospital mortality fell from 64.4% at hospitals without percutaneous coronary intervention to 36.5% at heart transplant centres.
Peer-reviewed -
Health todayDementia new
Most dementia trial participants had more than one brain pathology at autopsy
Among 67 autopsied participants in dementia trials at a Kentucky research centre, only 10 to 29% had solely the pathology that the trial's intervention was designed to target.
Peer-reviewed
