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Item refines preprint
Immunosuppressed people are less protected than their antibody levels would suggest
A meta-analysis of antibody responses to mRNA COVID-19 vaccination found binding antibody levels 54.5-fold lower in people on B-cell depleting therapy than in healthy controls, and protection against infection and hospitalisation lower at any given antibody level.
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Item confirms peer-reviewed
Carbapenem resistance tracked death in ICU-acquired bloodstream infection
Among 352 adults who developed a gram-negative bloodstream infection at least 48 hours after ICU admission, half the isolates were carbapenem-resistant and 30-day mortality was 57.9%, with resistance independently associated with death and appropriate early treatment with survival.
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Item new peer-reviewed
Carbapenemase-producing Enterobacterales doubled every 2.4 years in French hospitals
French national hospital surveillance for 2019 to 2024 found extended-spectrum beta-lactamase-producing Enterobacterales flat at 0.53 to 0.70 cases per 1,000 patient-days, while carbapenemase-producing Enterobacterales rose 32.8% a year from a far lower base, doubling every 2.4 years.
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Item refines peer-reviewed
Remote exercise rehabilitation raised peak oxygen uptake in cardiac patients
A meta-analysis of 13 randomised trials in 958 adults with cardiovascular disease found exercise-based telerehabilitation improved peak oxygen uptake by 2.58 mL/kg/min against usual care, on a 95% prediction interval running from -1.28 to 6.44 and substantial heterogeneity.
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Item refines peer-reviewed
Particulate matter shows no overall association with venous thromboembolism
An updated meta-analysis of 19 observational studies covering more than 4.5 million people found no significant overall association between long-term particulate exposure and venous thromboembolism, with a modest one appearing only among studies reporting in the same units.
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Item confirms preprint
Two influenza vaccine doses in a year tracked lower hospital mortality in Brazil
Among patients hospitalised with confirmed influenza in Brazil between 2023 and October 2025, a single trivalent vaccine dose was associated with 10-13% lower adverse outcomes and two doses within a calendar year with 32% lower in-hospital mortality.
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Item new preprint
Uvira's 2020 cholera vaccination campaign averted an estimated 56% of infections
A Bayesian model fitted to seven years of enhanced cholera surveillance in Uvira, Democratic Republic of the Congo, estimates that a 2020 oral vaccination campaign reaching 66% coverage averted 56% (95% CrI 34-81) of infections and deaths over the following three years.
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Item confirms peer-reviewed
Telehealth-supported hepatitis C care was costed at 69% below specialist care
A cost model of the Cherokee Nation's hepatitis C ECHO telehealth programme put care at $1412 per patient against $4534 under conventional specialist care, on that one system's own accounts for 2016 to 2020.
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Item refines peer-reviewed
Shared genetic risk across cancers appears only in specific regions, not genome-wide
An analysis of 16 cancers plus a pan-cancer phenotype found only 20 genome-wide correlated cancer pairs but 82 genomic regions with shared local effects across 66 pairs, with cross-cancer polygenic score associations concentrated in immune and inflammatory pathways.
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Item confirms peer-reviewed
RSV hospitalisations in older Brazilians rose after 2020, with case fatality 21-31%
National surveillance records show RSV-associated severe acute respiratory infection hospitalisations in Brazilians aged 60 and over rose from under 1 to over 15 per 100,000 between 2013 and 2024, with in-hospital case fatality of 21-31% and a mean stay of 12.9 days.
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Item refines peer-reviewed
Scotland's post-pandemic invasive strep A surge involved no new hypervirulent clone
Surveillance of 3,408 invasive group A streptococcus infections in Scotland from 2014 to 2024, with whole-genome sequencing of 404 emm1 isolates, found the late-2022 surge coincided with influenza and RSV activity rather than a genetically distinct clone.
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Item refines peer-reviewed
Cancer polygenic scores were weaker in African-ancestry than European-ancestry veterans
Among 560,287 US veterans, all 13 cancer-specific polygenic risk scores were associated with their own cancer in European-ancestry participants (OR 1.05 to 1.70 per standard deviation), but only 5 of 13 reached significance in African-ancestry participants, with smaller effects (OR 1.01 to 1.48).
