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Health todayCancer refines
Familial adenomatous polyposis found by screening matches general population mortality
Relatives found by family screening to have familial adenomatous polyposis had mortality comparable to the general population (median SMR 0.66), against 11.09 for patients presenting with symptoms.
Peer-reviewed -
Health todayDementia refines
Blood p-tau217 tracked Alzheimer's-type brain shrinkage but not ordinary ageing
Among 818 adults with no cognitive symptoms in the Baltimore Longitudinal Study of Aging, p-tau217 was the only blood marker associated with later shrinkage of the medial temporal lobe.
Preprint · not peer-reviewed -
Health todayCancer new
A model puts daraxonrasib at $500,637 per quality-adjusted life year in pancreatic cancer
A cost-effectiveness model built from the RASolute 302 trial put daraxonrasib at $500,637 per quality-adjusted life year gained over chemotherapy, at a US price of $39,800 per 30 days.
Preprint · not peer-reviewed -
Health todayCancer refines
Cancer polygenic scores were weaker in African-ancestry than European-ancestry veterans
Across 560,287 US veterans, all 13 cancer polygenic scores were associated with their own cancer in European-ancestry participants, but only five of 13 were in African-ancestry participants.
Peer-reviewed -
Health todayHeart and stroke new
Women and deprived patients had higher one-year mortality in English aortic disease
Among 33,793 new thoracic aortic disease diagnoses in England between 2013 and 2018, one-year mortality was higher among women, older patients and those from deprived areas, and patients from deprived areas were less likely to receive early intervention or genetic referral.
Peer-reviewed -
Health todayMental health new
One in five Black US students left the suicide attempt question blank
Across 163,489 US high school students surveyed from 2001 to 2021, the suicide attempt question was left blank by 21.6% of Black adolescents and 7.1% of white adolescents.
Peer-reviewed -
Health todayHeart and stroke confirms
Cochrane review pools 107 trials of exercise rehabilitation in coronary heart disease
An updated Cochrane review pooled 107 randomised trials in 26,886 adults with coronary heart disease, comparing exercise-based rehabilitation with no exercise on death, infarction and hospital admission.
Peer-reviewed -
Health todayDementia confirms
AT2-stimulating antihypertensives were linked to less dementia in two US cohorts
In 1.6 million Medicare beneficiaries and 80,267 Vanderbilt patients aged 65 and over with hypertension, incident Alzheimer's disease and related dementias were less common among users of angiotensin II receptor-stimulating than receptor-inhibiting antihypertensives (6.7% against 8.2% in Medicare).
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence confirms
Most US adults starting a GLP-1 obesity drug stop within the year
Among 201,229 insured US adults with obesity and no diabetes starting a GLP-1 drug, 30.7% stayed on it for most of the following year, as did 20.3% of paediatric patients.
Peer-reviewed -
Tomorrow's worldInnovation in treatment refines
Self-guided lifestyle app lowered LDL-cholesterol by 3.9% more than usual care
In a pragmatic online trial of 278 adults with LDL-cholesterol above target, a self-guided lifestyle app lowered LDL by 3.9% more than usual care at six months.
Preprint · not peer-reviewed -
Health todayCancer new
Fine particulate matter shows no association with ovarian cancer across pooled cohorts
A systematic review of 145 studies of environmental chemical exposures and gynaecologic cancers found no pooled association between PM2.5 and ovarian cancer (HR 1.02 per 5 µg/m³, 95% CI 0.91–1.13) and only a marginal one for endometrial cancer (HR 1.02, 95% CI 0.99–1.05).
Peer-reviewed -
Data, models and systemsAI in medicine new
Model using intake records predicted six-month deaths in Taiwanese care homes
A model built from routine intake assessments in 636 Taiwanese care homes predicted death within 180 days of admission, with an AUROC of 0.90 in a separate 2024 cohort.
Peer-reviewed
