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Health todayHeart and stroke refines
Bempedoic acid cut LDL cholesterol by 17.5% in German lipid clinics
In 641 patients at seven German lipid clinics, mean LDL cholesterol fell by 17.5% three months after bempedoic acid was added, and 26.7% had stopped the drug by then.
Peer-reviewed -
Health todayHeart and stroke refines
Slow restart of blood pressure drugs carried higher cardiovascular risk in SPRINT
In the SPRINT trial, participants whose blood pressure drugs were reduced and not promptly restored under the standard target had a 34% higher rate of major cardiovascular events.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Hip replacement after acetabular fracture in over-70s halved days to remobilisation
Among 60 patients aged 70 and over with displaced acetabular fractures at one trauma centre, acute hip arthroplasty was followed by walking at a median of three days against six after internal fixation, though allocation followed a changing protocol rather than randomisation.
Peer-reviewed -
Health todayDementia new
Rare damaging variants link IMPA2 to dementia and ANKRD27 to Parkinson's disease
A study of rare damaging gene variants in biobank and sequencing cohorts confirmed eight known dementia genes and newly linked IMPA2 to dementia and ANKRD27 to Parkinson's disease.
Preprint · not peer-reviewed -
Health todayCancer refines
Shared genetic risk across cancers sits in specific regions, not across the genome
Across 16 cancers, genome-wide analysis identified 20 correlated cancer pairs, whereas analysis region by region identified shared genetic signals across 66 pairs.
Peer-reviewed -
Health todayCancer confirms
Cancer risk in treated HIV followed age and smoking, not immune status
Among 7507 people with HIV on antiretroviral therapy, 219 cancers occurred over a median 5.6 years, with older age and current smoking associated with risk but immune markers not.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Type 2 diabetes fell by a quarter among Australian sleeve gastrectomy patients
Among 34,738 adults undergoing sleeve gastrectomy in New South Wales from 2017 to 2022, type 2 diabetes prevalence fell by 24.4%, and 72.3% had at least one cardiovascular risk factor.
Peer-reviewed -
Health todayCancer refines
PSA density separates later prostate cancer risk after a negative screening MRI
Among 1,685 men with a negative screening MRI, seven-year incidence of significant prostate cancer was 5.5% below a PSA density of 0.10 ng/mL2 and more than double that above it.
Peer-reviewed -
Health todayHeart and stroke new
Norwegian stroke rates fell over 20 years, except strokes linked to atrial fibrillation
Across 227,575 strokes in Norway from 2001 to 2021, ischaemic stroke fell from 204.4 to 130.8 per 100,000 person-years in people without atrial fibrillation, but not in those with it.
Peer-reviewed -
Health todayHeart and stroke new
Atrial fibrillation recurrence after ablation was similar on GLP-1, SGLT2 or both
Among adults having catheter ablation for atrial fibrillation, recurrence was similar on a GLP-1 drug, an SGLT2 inhibitor or both, while all-cause mortality was lower on the combination.
Peer-reviewed -
Health todayHeart and stroke refines
Heart-type fatty acid-binding protein detects coronary disease poorly but tracks deaths
Heart-type fatty acid-binding protein detected coronary disease poorly in 2,690 patients, but eight-year mortality rose from 7.7% in the lowest quartile of the marker to 44% in the highest.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 confirms
GLP-1/GIP agonist BGM0504 reduced weight by up to 18% at 24 weeks
In 120 Chinese adults with overweight or obesity and no diabetes, weekly BGM0504 reduced weight by 10.7% to 18.3% at 24 weeks, as compared to no change on placebo.
Peer-reviewed
