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Behavioural scienceSmoking and vaping refines
Seven in ten Korean heated tobacco and cigarette users moved to cigarettes
Among 7.26 million Korean adults screened between 2019 and 2023, users of heated tobacco or e-cigarettes were more likely to quit cigarettes, but also more likely to start smoking again.
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Tomorrow's worldInnovation in treatment new
Oral orforglipron is tested for cardiovascular safety against insulin in type 2 diabetes
A phase 3 trial randomised 2749 adults with type 2 diabetes and heart or kidney disease to oral orforglipron or insulin glargine, and followed them for a median two years.
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Data, models and systemsValue in health new
Sotagliflozin after worsening heart failure is modelled at $75,510 per QALY gained
A lifetime microsimulation of patients with type 2 diabetes after worsening heart failure put sotagliflozin at $75,510 per quality-adjusted life-year gained, at an assumed net cost of $434 a month.
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Health todayCancer refines
England's cervical screening coverage gap by deprivation has widened to 7.4 points
Cervical screening coverage in England in 2024 ranged from 73.5% in the least deprived areas to 66.1% in the most deprived, a wider gap than that recorded twelve years earlier.
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Health todayHeart and stroke refines
Never starting anticoagulants in atrial fibrillation carried the highest annual costs
Among 47,427 Scots with incident atrial fibrillation, annual healthcare costs were GBP 7,288 per patient on continuous oral anticoagulation and GBP 22,751 for those never started on it.
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Health todayHeart and stroke refines
Weight loss in impaired glucose tolerance went with fewer deaths over 34 years
In 540 Chinese adults with impaired glucose tolerance, a weight loss of 5% or more over six years carried a hazard ratio for death of 0.67 against no weight loss.
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Tomorrow's worldMedicine at a distance refines
Systolic pressure was 5.8 mmHg lower with apps and wearables after stroke
Across 29 studies in 8,389 stroke and transient ischaemic attack survivors, systolic blood pressure was 5.8 mmHg lower with mobile applications or wearables, though prediction intervals crossed the null.
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Data, models and systemsAI in medicine new
A blood protein score of cellular ageing predicted death in UK Biobank
A blood protein score of cellular ageing, built in UK Biobank, predicted death and later dementia, COPD, heart attack and stroke, and changed over 18 months with exercise.
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Behavioural scienceAdherence and persistence new
Fewer than one in five US stroke and TIA patients filled a P2Y12 inhibitor
Among 45,763 US adults with a first ischaemic stroke or TIA, 18.9% filled a P2Y12 inhibitor within 30 days, and half of clopidogrel initiators had stopped filling by 180 days.
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Data, models and systemsHealth systems and access confirms
Adult mortality is 26% higher for those whose fathers held lower-ranked jobs
A meta-analysis of 102 cohort studies covering about 8.5 million people in 24 countries found adult all-cause mortality 26% higher for those whose fathers held lower-ranked occupations.
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Behavioural scienceAdherence and persistence refines
Tirzepatide initiators stayed on treatment longer than semaglutide initiators
In propensity-matched US claims data on adults with type 2 diabetes, 12-month adherence was 60% for tirzepatide initiators against 45% for semaglutide initiators among GLP-1-naive patients, with persistence of 62% against 47%.
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Tomorrow's worldSlowing ageing itself refines
Proteomic organ clocks tracked 16-year mortality less closely than epigenetic age
Accelerated liver, immune and heart proteomic ageing carried hazard ratios of 1.38 to 1.43 per standard deviation for 16-year mortality, below those for epigenetic age and cognition.
Peer-reviewed
