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Health todayObesity, diabetes and GLP-1 new
GLP-1 prescribing to US children aged 8-11 with obesity rose but stayed under 1%
Among 3.5 million US children aged 8 to 11 with obesity and without diabetes recorded in Epic Cosmos between 2019 and June 2026, 0.6% received a GLP-1 receptor agonist prescription, with rates highest among 11-year-olds, girls, and those with obesity-related comorbidities.
Peer-reviewed -
Tomorrow's worldA changing climate new
Daily cancer deaths in Japan were 0.88% higher per 10 micrograms/m3 of PM2.5
A 10 microgram per cubic metre rise in PM2.5 was associated with 0.88% more cancer deaths in Japan, though the association did not survive adjustment for NO2 or SO2.
Peer-reviewed -
Data, models and systemsAI in medicine new
Language models identified overdose deaths from New York investigators' written reports
Reading the reports New York City death investigators write on each case, the better of two language models identified suspected overdose deaths with 92% sensitivity and 88% positive predictive value.
Peer-reviewed -
Data, models and systemsValue in health new
Modelled depression screening of KwaZulu-Natal sex workers averts HIV at $490 per QALY
A transmission model for KwaZulu-Natal found depression screening with behavioural treatment most cost-effective among female sex workers, at $350 per HIV infection averted and $490 per QALY gained.
Peer-reviewed -
Behavioural scienceAlcohol and drug use new
One in nine older US cannabis users meets criteria for cannabis use disorder
In a national US survey, 8.9% of adults aged 65 and over had used cannabis in the past year, and 11.4% of those met criteria for cannabis use disorder.
Peer-reviewed -
Tomorrow's worldSlowing ageing itself new
Uncertainty in a biological age estimate is itself associated with mortality
In over 450,000 UK Biobank participants, the uncertainty of a biological age estimate was associated with mortality, multimorbidity and loss of healthspan independently of the age gap itself.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
Modelled hepatitis B cure is cost-effective under USD46,642 a course in the US
A Markov model estimated that a hepatitis B cure regimen working in 30% of patients would be cost-effective at a one-off price below USD46,642 in the US.
Peer-reviewed -
Data, models and systemsRevisions and new sources new
Electronic death notification in Zambia lifted completeness from 11.9% to 17.4%
An electronic version of Zambia's death notification form, used in burial offices across four provinces, cut the mean reporting delay from six days to three.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
Oral GLP-1 tablet safiglipron cut HbA1c by up to 1.45 points in type 2 diabetes
In the OUTSTAND-1 trial, once-daily safiglipron tablets lowered HbA1c by up to 1.45 percentage points more than placebo over 32 weeks in untreated type 2 diabetes.
Peer-reviewed -
Behavioural scienceSocial connection refines
Loneliness predicts psychological distress better than other social measures
In a 29-country European survey of 48,377 respondents, loneliness was the strongest social predictor of psychological distress, and the other social measures together added 0.006 to the AUC.
Peer-reviewed -
Health todayDementia refines
APOE e4 dementia risk is largest in European ancestry across 367,757 US adults
A study of APOE genotype against 2,632 traits and conditions in 367,757 All of Us participants found 27 associations, with dementia risk largest in those of European ancestry.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics refines
Modelling puts maternal deaths 68,489 above pre-pandemic trends over 2020 to 2023
Models fitted to WHO/UN estimates for 2000 to 2019 put maternal deaths for 2020 to 2023 at 68,489 above the projected path, with excess detectable in 113 of 195 countries.
Preprint · not peer-reviewed
