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Health todayCancer confirms
Lower nutrition-inflammation score went with higher mortality in ICU kidney injury
In 1,887 intensive care patients with acute kidney injury, a higher nutrition and inflammation score was associated with lower in-hospital mortality, at a hazard ratio of 0.86 per log unit.
Peer-reviewed -
Data, models and systemsRevisions and new sources new
Amish study of 3,978 adults links cognitive diagnoses to pedigrees and whole-genome data
The Collaborative Amish Aging and Memory Project has enrolled 3,978 Amish adults in Ohio and Indiana, 2,928 with an agreed cognitive diagnosis, and reports only the cohort's composition.
Preprint · not peer-reviewed -
Data, models and systemsAI in medicine confirms
Machine learning predicted HPV vaccine hesitancy no better than logistic regression
Among 1,156 parents in Buea Health District, Cameroon, logistic regression, random forest and gradient boosting identified hesitant parents equally well, with area under the curve between 0.841 and 0.870.
Preprint · not peer-reviewed -
Health todayDementia confirms
Glial injury marker GFAP separates Alzheimer's stages more sharply than vascular markers
Among 2650 ADNI participants, the glial injury marker GFAP was 56.3% higher in Alzheimer's dementia than in unimpaired people, whereas vascular markers differed by around 14% and discriminated poorly.
Peer-reviewed -
Behavioural scienceInfection and pandemics new
Wastewater bacteria tracked community COVID-19 case rates alongside viral load
A preprint reports that gut bacteria depleted during infection tracked COVID-19 case rates in wastewater, with bacteria alone predicting future rates modestly better than bacteria plus viral gene copies.
Preprint · not peer-reviewed -
Behavioural scienceInfection and pandemics new
Mass cholera vaccination in Uvira, DRC, averted an estimated 56% of infections
Modelling of cholera surveillance in Uvira, Democratic Republic of the Congo, estimates that the 2020 vaccination campaign averted 56% of infections and deaths over the following three years.
Preprint · not peer-reviewed -
Health todayHeart and stroke new
Spleen uptake on cardiac PET stress scans is associated with later cardiac events
Among 16,650 patients having drug-stress cardiac PET at six sites, a high ratio of spleen uptake under stress to uptake at rest was associated with more major cardiovascular events.
Peer-reviewed -
Health todayHeart and stroke refines
Bempedoic acid cut LDL cholesterol by 17.5% in German lipid clinics
In 641 patients at seven German lipid clinics, mean LDL cholesterol fell by 17.5% three months after bempedoic acid was added, and 26.7% had stopped the drug by then.
Peer-reviewed -
Health todayHeart and stroke refines
Slow restart of blood pressure drugs carried higher cardiovascular risk in SPRINT
In the SPRINT trial, participants whose blood pressure drugs were reduced and not promptly restored under the standard target had a 34% higher rate of major cardiovascular events.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Hip replacement after acetabular fracture in over-70s halved days to remobilisation
Among 60 patients aged 70 and over with displaced acetabular fractures at one trauma centre, acute hip arthroplasty was followed by walking at a median of three days against six after internal fixation, though allocation followed a changing protocol rather than randomisation.
Peer-reviewed -
Health todayDementia new
Rare damaging variants link IMPA2 to dementia and ANKRD27 to Parkinson's disease
A study of rare damaging gene variants in biobank and sequencing cohorts confirmed eight known dementia genes and newly linked IMPA2 to dementia and ANKRD27 to Parkinson's disease.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep confirms
Kidney stones were half as common in UK Biobank adults with healthier habits
Among 300,875 UK Biobank adults followed for a median of 12.3 years, those meeting most of seven healthy habits had half the kidney stone risk of those meeting fewest.
Peer-reviewed
