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Data, models and systemsValue in health new
Perioperative enfortumab vedotin and pembrolizumab in cisplatin-ineligible bladder cancer
In a Markov model, perioperative enfortumab vedotin plus pembrolizumab cost $72,460 per QALY gained versus radical cystectomy alone.
Peer-reviewed -
Behavioural scienceAdherence and persistence refines
Semaglutide: 14.5% of US initiators start at high dose, with earlier discontinuation
Among US adults starting injectable semaglutide, high-dose initiation was associated with a 25% higher early discontinuation risk and lower 1-year persistence.
Peer-reviewed -
Data, models and systemsValue in health new
Housing for homeless Californians with opioid use disorder modelled at $31,083 per QALY
A lifetime microsimulation of 18,928 Californians experiencing homelessness with opioid use disorder gave $31,083 per quality-adjusted life-year from expanding housing access.
Preprint · not peer-reviewed -
Data, models and systemsWhat linked data reveals contradicts
Polygenic modification of statin benefit may arise from trial eligibility criteria
Simulations with no true interaction reproduced the reported pattern of greater lipid-lowering benefit at higher coronary artery disease polygenic risk.
Preprint · not peer-reviewed -
Data, models and systemsValue in health new
US childhood hepatitis B vaccine policy changes modelled to increase chronic infections
A Markov model of a 3.6 million US birth cohort projects 83% more childhood chronic hepatitis B infections under shared decision making.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 refines
Type 2 diabetes remission and relapse after metabolic-bariatric procedures in ARMMS-T2D
In ARMMS-T2D, 58% assigned to metabolic-bariatric procedures reached diabetes remission over a median 11 years, against 3% on medical-lifestyle care.
Peer-reviewed -
Health todayFrailty and multimorbidity refines
Plant-based diet indices and frailty in 8,628 older adults across three ageing cohorts
Higher overall plant-based scores were associated with lower frailty risk (ORs 0.71-0.80), unhealthful scores with higher risk (1.24-1.41).
Peer-reviewed -
Data, models and systemsHealth systems and access new
Behavioural health ED patients leaving unseen return, are admitted and die more often
Among 1,305,812 US emergency department behavioural health episodes, a 7-day return visit followed 24.5% of those leaving without being seen, against 13.2% after completed care.
Preprint · not peer-reviewed -
Behavioural scienceSmoking and vaping refines
E-cigarette flavour use and later vaping abstinence in US youth and adults, PATH 2016-2023
Exclusive tobacco or flavourless vaping preceded higher odds of 30-day e-cigarette abstinence, while use of multiple flavours preceded lower odds.
Peer-reviewed -
Data, models and systemsForecasts and their record new
US obesity treatment access modelled as 5.3 million preventable deaths over a decade
Modelling projects 5.3 million preventable deaths and $10.5-13.3 trillion foregone benefits over a decade of restricted obesity treatment access.
Peer-reviewed -
Health todayObesity, diabetes and GLP-1 new
GLP-1 agonists and atrial fibrillation in non-diabetic obesity with kidney disease
GLP-1 users with obesity and CKD had 1.63% one-year incident atrial fibrillation, against 2.62% in unexposed patients.
Peer-reviewed -
Behavioural scienceInfection and pandemics refines
Influenza antibody titres waned by strain, not uniformly, in Michigan and Hong Kong
H1N1 titres fell in Michigan and two H3N2 strains fell in Hong Kong; other strains changed little.
Preprint · not peer-reviewed
