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Item new preprint
England's ECHILD linkage under-covers deprived and minoritised ethnic children
ECHILD, which links hospital, school and social care records for 21 million children in England, found lower coverage in London, deprived areas and minoritised ethnic groups, with 90% of birth records linked to school records and 88% of pupils linked to a patient record.
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Item new preprint
Gaussian process models fill gaps in Canada's patchy measles vaccine coverage data
A Canadian preprint uses Gaussian process models to impute missing measles vaccine coverage by province, territory and age, creating a complete modelled coverage dataset for outbreak response work and testing the approach against England's more complete records.
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Item confirms peer-reviewed
A random forest beat logistic regression at predicting death in US diabetic adults
In 2428 US adults with both type 2 diabetes and hypertension from NHANES 1999-2018, a random forest model predicted all-cause mortality with an AUC of 0.873, against 0.783 for logistic regression, with no external validation reported.
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Item new peer-reviewed
Later Chinese cohorts spend more years happy, with gaps widening by education
A cohort-based multistate life table analysis of the Chinese Longitudinal Healthy Longevity Survey for 2002 to 2018 found later-born cohorts of older adults spent a higher proportion of life happy at every age range, with larger gains for women, urban residents and the formally educated.
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Item refines preprint
AI on breast biopsy slides flagged intermediate-risk patients who gained from chemotherapy
Applied without retraining to 6,735 TAILORx trial participants, an AI model reading H&E slides alongside clinical variables predicted disease-free interval (C-index 0.736) and, within the intermediate-risk group, separated patients who gained from chemotherapy from those who did not.
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Item new peer-reviewed
Care-experienced Scottish children had roughly triple the mental health admission risk
Linking Scottish social care and hospital records for 663,601 children born between 1990 and 2004 and followed to 2016, care-experienced girls had a hazard ratio of 3.22 and boys 2.64 for a first mental health hospitalisation, with higher ratios still for repeat admissions.
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Item refines peer-reviewed
Austrian all-cause mortality in 2024 sat at or below 2019 at every age over 60
An Austrian analysis of 2024 death certificates found all-cause mortality equal to or below 2019 in every group aged 60 and over despite 1,212 reported COVID-19 deaths, while weighting contributing causes put the COVID death rate at 0.51 to 0.58 of the unweighted figure.
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Item confirms peer-reviewed
US life expectancy ranked 38th in 2023 as the gap with peer countries widened
An analysis of US and comparator mortality data finds US life expectancy ranked 38th globally in 2023, with the gap against 16 high-income countries widening and the rising death rates concentrated at younger and working ages.
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Item confirms peer-reviewed
AI models predict death after hip fracture but are seldom externally validated
A systematic review of 40 studies published between 2010 and 2026 found that machine learning models for outcomes after hip fracture, most often death, achieved moderate to strong discrimination but were limited by inconsistent external validation and sparse calibration.
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Item refines peer-reviewed
Whole-genome sequencing gave a genetic diagnosis in 4.9% of kidney anomaly cases
Whole-genome sequencing of 1,052 people with congenital anomalies of the kidney and urinary tract in the UK 100,000 Genomes Project gave a single-gene diagnosis in 4.9%, with common and low-frequency variants estimated to explain 23% of phenotypic variance.
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Item confirms peer-reviewed
Modelled measles scale-up in Kenya averts 879 deaths over ten years
A Markov model of measles vaccination in Kenya estimated that maintaining current funding would avert 213 deaths over ten years at $1,269 per DALY averted, while reaching 95% two-dose coverage would avert 879 deaths at $1,093 per DALY averted, at a very high cost to the health budget.
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Item new preprint
An Amish founder-population cohort links genomes and cognition in 3,978 older adults
The Collaborative Amish Aging and Memory Project has enrolled 3,978 older Amish adults in Ohio and Indiana, 2,928 with consensus-adjudicated cognitive status, alongside multigenerational pedigrees, whole-genome sequencing and plasma biomarkers, and reports no findings beyond its composition.
