-
Data, models and systemsForecasts and their record refines
Pandemic excess deaths were partly offset by a death deficit in 2024 and 2025
Across 38 countries with reliable death registration, excess deaths of 1.99-2.88 million in 2020-2023 were followed by a deficit of 0.39-1.08 million in 2024-2025.
Preprint · not peer-reviewed -
Health todayHeart and stroke refines
New heart failure was slightly less common on tirzepatide than semaglutide
Among 424,269 matched pairs of patients with obesity in the TriNetX records, one-year new-onset heart failure was 1.0% on tirzepatide and 1.3% on semaglutide.
Preprint · not peer-reviewed -
Data, models and systemsAI in medicine new
AI-guided ultrasound by operators without ultrasound training detected 93% of leg clots
Scans taken under AI guidance by operators without ultrasound training identified 92.9% of proximal deep vein thromboses, with 98.0% specificity in flagging who still needed a standard ultrasound.
Preprint · not peer-reviewed -
Behavioural scienceAdherence and persistence refines
Seven in ten US women stay on endocrine therapy for one year
Of 401,450 US women starting adjuvant endocrine therapy after breast surgery, 69.9% had a medication possession ratio of at least 80% over the first year.
Preprint · not peer-reviewed -
Data, models and systemsAI in medicine refines
Polygenic scores add most to prediction where clinical risk is already low
Across 150 diseases in 900,000 UK Biobank and FinnGen participants, polygenic scores added most in metabolic, cardiovascular, autoimmune and neurological disease, and added little for genitourinary and respiratory conditions.
Preprint · not peer-reviewed -
Health todayDementia new
28% of middle-aged and older Canadians know of the hearing loss-dementia link
A survey of 1,404 Canadians found that 28% were aware of the hearing loss-dementia link, and 17% of those aware were more inclined to seek hearing-loss treatment.
Preprint · not peer-reviewed -
Health todayCancer new
Myelosuppression is gemcitabine's most consistent signal in FDA adverse event reports
In 18.37 million adverse event reports made to the FDA since 2014, myelosuppression was reported 3.35 to 7.74 times more often with gemcitabine regimens than with other drugs.
Preprint · not peer-reviewed -
Behavioural scienceAlcohol and drug use refines
Scottish drug deaths rose 11% in 2025, with nitazenes linked to a fifth of fatalities
Drug-related deaths in Scotland rose by 11% to 1133 in 2025, with 247 (22%) linked to nitazenes, more than triple the 2024 figure, although routine postmortem testing for etonitazene began only in May 2025.
Official statistics -
Data, models and systemsValue in health new
G6PD-guided primaquine package costs US$6,636 per DALY averted in Indonesia
A decision-tree model of G6PD screening with high-dose primaquine for Plasmodium vivax in Indonesia gave US$6,636 per DALY averted, above the willingness-to-pay threshold of one GDP per capita.
Preprint · not peer-reviewed -
Data, models and systemsRevisions and new sources new
UK database lists the additives that mark a food as ultra-processed
Researchers have sorted every additive approved in the UK by its purpose, so that those used to alter taste, colour or texture mark a product as ultra-processed.
Preprint · not peer-reviewed -
Data, models and systemsForecasts and their record new
Modelled summer COVID-19 vaccination averts more US hospitalisations in over-65s
A US transmission model estimated 441 COVID-19 hospitalisations per 100,000 adults aged 65 and over under July vaccination, as compared to 578 with no further vaccination.
Preprint · not peer-reviewed -
Behavioural scienceDiet, exercise and sleep refines
Older adults walked 483 fewer steps after a day of higher fine particle exposure
In 67 UK adults aged 50-85, a day on which fine particle exposure ran 2.6 micrograms per cubic metre above the person's own average was followed by 483 fewer steps.
Preprint · not peer-reviewed
